- Original Article
- Cardiology
- High antistreptolysin O titer is associated with coronary artery lesions in patients with Kawasaki disease
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Dong Eun Min, Do Hee Kim, Mi Young Han, Sung Ho Cha, Kyung Lim Yoon
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Clin Exp Pediatr. 2019;62(6):235-239. Published online November 7, 2018
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Purpose: In Kawasaki disease (KD) patients, coronary artery complications, incomplete and refractory types occur more frequently in patients with streptococcal or other bacterial/viral infections. Recently, we observed a higher incidence of coronary lesions in KD patients with high anti-streptolysin O (ASO) titer. Therefore, we hypothesized that KD patients diagnosed with concurrent streptococcal infection have poor prognosis, with respect to treatment... |
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- Analysis of clinical characteristics and causes of chest pain in children and adolescents
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Ji Hye Chun, Tae Hyeong Kim, Mi Young Han, Na Yeon Kim, Kyung Lim Yoon
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Clin Exp Pediatr. 2015;58(11):440-445. Published online November 22, 2015
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Purpose Chest pain is common in children and adolescents and is a reason for referral to pediatric cardiologists. Although most cases of chest pain in these age groups are benign and do not require treatment, timely diagnosis is important not to miss life-threatening diseases requiring prompt treatment. We investigated certain clinical characteristics that may be useful in the diagnosis of such... |
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- Transforming growth factor beta receptor II polymorphisms are associated with Kawasaki disease
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Yu Mi Choi, Kye Sik Shim, Kyung Lim Yoon, Mi Young Han, Sung Ho Cha, Su Kang Kim, Joo Ho Jung
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Clin Exp Pediatr. 2012;55(1):18-23. Published online January 31, 2012
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Purpose Transforming growth factor beta receptor 2 (TGFBR2) is a tumor suppressor gene that plays a role in the differentiation of striated cells and remodeling of coronary arteries. Single nucleotide polymorphisms (SNPs) of this gene are associated with Marfan syndrome and sudden death in patients with coronary artery disease. Cardiovascular remodeling and T cell activation of TGFBR2 gene suggest that the... |
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- Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population
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Kyung Lim Yoon, Jin Hee Ko, Kye Shik Shim, Mi Young Han, Sung Ho Cha, Su Kang Kim, Joo Ho Jung
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Clin Exp Pediatr. 2011;54(8):335-339. Published online August 31, 2011
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Purpose Hyperhomocysteinemia is known as a risk factor for atherosclerosis. Preclinical arteriosclerosis is noted and premature atherosclerosis is known to be accelerated in Kawasaki disease (KD) patients. Genetic polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene result in elevated plasma homocysteine concentrations and are known to be associated with the development of coronary artery disease. Our hypothesis is that single nucleotide polymorphisms... |
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- The relationship between catechol-O-methyltransferase gene polymorphism and
coronary artery abnormality in Kawasaki disease
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Hyo Jin Lee, Myung Sook Lee, Ji Sook Kim, Eun Ryoung Kim, Sung Wook Kang, Soo Kang Kim, Joo Ho Chun, Kyung Lim Yoon, Mi Young Han, Seong Ho Cha
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Clin Exp Pediatr. 2009;52(1):87-92. Published online January 15, 2009
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Purpose : Many gene polymorphisms are associated with coronary artery abnormalities in Kawasaki disease. Catechol-O- methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catechol estrogen, and catechol drugs. Polymorphisms of the COMT gene are reported to be associated with myocardial infarction and coronary artery abnormalities. The aim of this study was to evaluate the relationship between COMT... |
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- The factors associated with the efficacy of indomethacin treatment in premature infants with patent ductus arteriosus
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Min Jeong Yoon, Hye Sun Yoon, Sung Hoon Chung, Mi Young Han, Chong Woo Bae
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Clin Exp Pediatr. 2007;50(6):531-535. Published online June 15, 2007
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Purpose : Indomethacin treatment is successful in about 90% of patent ductus arteriosus (PDA) in premature infants, but in some, repeated administration or surgical closure is required. The object of the present study is to determine the factors affecting the efficacy of indomethacin treatment and to predict the treatment result.
Method : The 29 preterm neonates, admitted to neonatal intensive... |
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- Polymorphism in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene in Kawasaki disease
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Mi Young Han
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Clin Exp Pediatr. 2007;50(6):570-575. Published online June 15, 2007
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Purpose : To demonstrate genetic background of pathogenesis of Kawasaki disease (KD), I examined the genetic polymorphism of plasminogen activator inhibitor-1 (PAI-1) in KD patients.
Methods : PCR-RFLP of PAI- 1 promotor gene was analyzed in 56 KD patients admitted to Kyunghee University Hospital, Gachon Medical School Gil Hospital, and Eulji Hospital from March to August 2000 and 206 normal... |
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- Case Report
- Surgical removal of a left ventricular thrombus caused by acute myocarditis
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Kyu Ha Lee, Min Jung Yoon, Mi Young Han, Sa Jun Chung, Soo Cheol Kim
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Clin Exp Pediatr. 2007;50(6):588-591. Published online June 15, 2007
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Left ventricular thrombus is mainly caused by anterior myocardial infarction or severe cardiac wall dysfunction of the apex, and is rarely caused by a complication of acute myocarditis. A 12-year-old female who developed symptoms of motor dysphasia and incomplete hemiparesis of the right side was admitted to the hospital. The brain MRI taken on the day of her admission showed... |
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- Original Article
- Study for Balloon Aortic Valvuloplasty in Congenital Aortic Stenosis
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In Seung Park, Do Jun Cho, Mi Young Han, Jae Young Lee, Soo Jin Kim, Mee-Hye Oh, Eun Jung Bae, Seong Ho Kim
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Clin Exp Pediatr. 2001;44(2):167-176. Published online February 15, 2001
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Purpose : The aims of this study are to investigate the results of balloon aortic valvuloplasty (BAV) in congenital aortic stenosis(CAS) and, especially, to compare the results between BAV performed before two months of age(Group A) and BAV after two month of age(Group B).
Methods : From January 1993 to June 2000, 14 patients who were diagnosed as CAS were treated... |
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- Case Report
- A Case of Transcatheter Occlusion of Aortopulmonary Window(APW) after APW Banding
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Young Seok Lee, In Seung Park, Jae Young Lee, Soo Jin Kim, Mi Young Han, Do Jun Cho, Eun Jung Bae, Seong Ho Kim
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Clin Exp Pediatr. 2000;43(9):1290-1293. Published online September 15, 2000
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Aortopulmonary window is an uncommon cardiac anomaly accounting for approximately 0.2-0.6% of all congenital cardiac anomalies in which there is a connection between the ascending aorta and pulmonary trunk. Since the first report of successful surgical repair, many investigators have advocated surgical closure of all types of aortopulmonary windows using different technique. The majority of aortopulmonary windows require surgical therapy... |
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- Original Article
- Management of Post-operative Pulmonary Artery Stenosis in Tetralogy of Fallot
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Young Seok Lee, In Seung Park, Jae Young Lee, Soo Jin Kim, Mi Young Han, Do Jun Cho, Eun Jung Bae, Seong Ho Kim
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Clin Exp Pediatr. 2000;43(8):1081-1089. Published online August 15, 2000
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Purpose : Pulmonary artery stenosis is a common finding in post-operative tetralogy of Fallot (TOF), and it is one of the most frequent indication of reoperation. The objective of this study was to determine the procedural success rate of balloon angioplasty(BAP), endovascular stent, and reoperation for pulmonary artery stenosis in terms of its clinical impact on the subsequent management of... |
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- Repair of Corrected Transposition of the Great Arteries
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Soo Jin Kim, Young Seok Lee, Mi Young Han, Jae Young Lee, Do Jun Jo, In Seung Park, Eun Jung Bae, Chang-Ha Lee, Woong-Han Kim, Young-Tak Lee, Seong Ho Kim
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Clin Exp Pediatr. 2000;43(8):1074-1080. Published online August 15, 2000
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Purpose : To assess the clinical characteristics and surgical approaches in different anatomical and hemodynamic types of corrected transposition of great arteries(TGA) and learn the surgical results of those patients.
Methods : All 52 patients who were diagnosed as corrected TGA between December 1987 and November 1999 and their medical records were reviewed. Three groups were identified according to associated anomalies;... |
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- Follow up of Patients with Total Anomalous Pulmonary Venous Return in Right Atrial Isomerism
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Soo Jin Kim, Jae Young Lee, Mi Young Han, Do Jun Jo, In Seung Park, Mee-Hye Oh, Eun Jung Bae, Seong Ho Kim
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Clin Exp Pediatr. 2000;43(11):1451-1457. Published online November 15, 2000
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Purpose : Total anomalous venous return(TAPVR) is associated in more than 60% of patients with right isomerism and can significantly complicate the management of single ventricle patients at any stage of management. We studied the results of management and sought to determine factors that may influence survival in patients with TAPVR in right atrial isomerism.
Methods : Between February 1991 and... |
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- Study of Congenital Mitral Stenosis Cases Requiring Surgical Correction in the First 2-Years of Life
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In Seung Park, Young Seok Lee, Mi Young Han, Jae Young Lee, Soo Jin Kim, Do Jun Cho, Mee-Hye Oh, Woong-Han Kim, Young-Tak Lee, Eun Jung Bae, Seong Ho Kim
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Clin Exp Pediatr. 2000;43(11):1458-1464. Published online November 15, 2000
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Purpose : Congenital mitral stenosis(CMS) is a rare anomaly accounting for 0.4-0.5% of total heart disease. CMS which cases needed surgical correction in infancy are even rare. In this study, we analyzed 11 CMS patients of less than 2 year of age who needed surgical corrections, in order to find out their diagnoses, the characteristics, the results of operation and... |
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- Early Results of Stent Implantation in Branch Pulmonary Artery Stenosis after Tetralogy of Fallot Repair
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Sung Kyu Lee, Sang Hun Lee, Jae Young Lee, Su Jin Kim, Mi Young Han, Do Jun Cho, In Seung Park, Eun Jung Bae, Sung Ho Kim
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Clin Exp Pediatr. 2000;43(10):1343-1349. Published online October 15, 2000
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Purpose : Pulmonary artery stenosis is mainly complicated by aortopulmonary shunt or total correction of tetralogy of Fallot(TOF). Results of surgical angioplasty are poor and the success rate of balloon angioplasty is 53-72%. Endovascular stents have been applied to these lesions. The purpose of this study is to evaluate the early results of stent implantation in postoperative pulmonary artery stenosis... |
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- Treatment of Pulmonary Atresia, Ventricular Septal Defect and Diminutive Pulmonary Arteries Comparing First Palliative Management Schemes
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Jean Yoon, In Seung Park, Soo Jin Kim, Mi Young Han, Do Jun Cho, Eun Jung Bae, Young Tak Lee, Seong Ho Kim
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Clin Exp Pediatr. 1999;42(6):800-806. Published online June 15, 1999
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Purpose : This report reviews an 8-year treatment of pulmonary atresia, ventricular septal defect and diminutive pulmonary arteries, comparing first palliative management schemes.
Methods : Between January 1989 and March 1997, patients had their pulmonary artery anatomy evaluated before any surgical managements. Twenty-two patients had diminutive pulmonary arteries(Nakata index<90). Clinical records, hemodynamic data, and cineangiograms were examined in these patients.
Results... |
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